Multistage optimal control for microbial fed-batch fermentation process
نویسندگان
چکیده
منابع مشابه
Optimal switching control of a fed-batch fermentation process
Considering the hybrid nature in fed-batch culture of glycerol biconversion to 1,3-propanediol (1,3-PD) by Klebsiella pneumoniae, we propose a state-based switching dynamical system to describe the fermentation process. To maximize the concentration of 1,3-PD at the terminal time, an optimal switching control model subject to our proposed switching system and constraints of continuous state ine...
متن کاملModelling and Optimal Control for Nonlinear Multistage Dynamical System of Microbial Fed-batch Culture
In this paper, we propose a new controlled multistage system to formulate the fed-batch culture process of glycerol bio-dissimilation to 1,3propanediol (1,3-PD) by regarding the feeding rate of glycerol as a control function. Compared with the previous systems, this system doesn’t take the feeding process as an impulsive form, but a time-continuous process, which is much closer to the actual cu...
متن کاملEvolutionary Algorithms for Optimal Control in Fed-Batch Fermentation Processes
In this work, Evolutionary Algorithms (EAs) are used to achieve optimal feedforward control in a recombinant bacterial fed-batch fermentation process, that aims at producing a bio-pharmaceutical product. Three different aspects are the target of the optimization procedure: the feeding trajectory (the amount of substrate introduced in a bioreactor per time unit), the duration of the fermentation...
متن کاملOptimal Adaptive Control of Fed-batch Fermentation Processes
This paper presents a unifying methodology for optimization of biotechnological processes, namely optimal adaptive control, which combines the advantages of both the optimal control and the adaptive control approaches. As an example, the design of a substrate feeding rate controller for a class of biotechnologlcal processes in stirred tank reactors characterized by a decoupling between biomass ...
متن کاملOptimal Control of a Fed-Batch Fermentation Involving Multiple Feeds
A nonlinear dynamical system, in which the feed rates of glycerol and alkali are taken as the control functions, is first proposed to formulate the fed-batch culture of 1,3-propanediol 1,3-PD production. To maximize the 1,3-PD concentration at the terminal time, a constrained optimal control model is then presented. A solution approach is developed to seek the optimal feed rates based on contro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Industrial & Management Optimization
سال: 2021
ISSN: 1553-166X
DOI: 10.3934/jimo.2021040